Clinical Studies

References, By Product.

At The Gut Co., we want to help you make healthy choices, and those choices start with understanding the ingredients in your supplements.

We combed through the most important and trusted clinical studies in the gut health space in order to create supplements that contain the EXACT ingredients proven to be most effective in EXACTLY the right doses. 

Please find our references for each product below.

Gut Care Studies


4 Ansel et al. (2015) - Kiwifruit-derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study - Nutrition Research

This study demonstrated that Actazin produced clinically meaningful increases in bowel movements in healthy individuals. Consumption of Actazin significantly increased the number of daily bowel movements by greater than 1 bowel movement per week. 

5 Blatchford et al. (2017) - Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomised controlled human trial - Journal of Nutritional Science

This study found that the abundance of Faecalibacterium prausnitzii, a beneficial microbe, significantly increased following kiwifruit capsule supplementation by 3.4 to 7%.

Wang et al. (2018) - Bioactive Compounds and in vitro antioxidant activities of peel, flesh, and seed powder of kiwi fruit - Institute of Food Science and Technology.

This study found that the compounds of kiwifruit make for promising ingredients for use in the enrichment of products providing dietary fibre, bioactive compounds, and antioxidant action.


Agric. Et al. (2010) - Actinidin Enhances Protein Digestion in the Small Intestine As Assessed Using an in Vitro Digestion Model - American Chemical Society.

This study found that kiwifruit influenced the digestion patterns of all of the proteins in the small intestine.

Saccharomyces Boulardii

5 6 McFarland, L. (2010) - Systematic review and meta-analysis of Saccharomyces boulardii in adult patients - World Journal of Gastroenterology.

In adults, Saccharomyces Boulardii, a beneficial yeast, can be strongly recommended for the prevention of antibiotic-associated diarrhea and traveller’s diarrhea. This study also supports the use of this yeast probiotic for the prevention of enteral nutrition-related diarrhea and reduction of Helicobacter pylori treatment-related symptoms. S.Boulardii is also showing promise for helping to prevent IBS and acute diarrhea. Of 31 randomized, placebo-controlled treatment arms in 27 trials (encompassing 5029 study patients), S. boulardii was found to be significantly efficacious and safe in 84% of those treatment arms.

Czerucka et al. (2007) - Review article: Yeast as probiotics - Saccharomyces boulardii - Aliment Pharmacol Ther.

An earlier study outlining promising research perspectives being opened in terms of maintenance treatment of inflammatory bowel diseases. Experimental studies clearly demonstrate the probiotic properties of Saccharomyces boulardii, opening the door for new therapeutic uses of this yeast as an ‘immunobiotic’.

Guslandi et al. (2000) - Saccharomyces boulardii in Maintenance Treatment of Crohn’s Disease - Digestive Disease and Sciences.

Results suggest that Saccharomyces boulardii may represent a useful tool in the maintenance treatment of Crohn’s Disease. Thirty-two patients with Crohn's disease in clinical remission (CDAI < 150) were randomly treated for six months with either mesalamine 1 g three times a day or mesalamine 1 g two times a day plus a preparation of Saccharomyces boulardii 1 g daily. Clinical relapses as assessed by CDAI values were observed in 37.5% of patients receiving mesalamine alone and in 6.25% of patients in the group treated with mesalamine plus the probiotic agent.

Sivananthan et al. (2018) - Review of Saccharomyces boulardii as a treatment option in IBD - Immunopharmacology and Immunotoxicology.

Three clinical trials showed a positive effect of S.boulardii in IBD patients (two Crohn’s disease and one ulcerative colitis). Some animal trials and cell assays describe different anti-inflammatory mechanisms of S.boulardii supporting a possible effect when treating IBD patients.  


1 Silvie et al. (2014) - Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines - International Journal of Food Sciences & Nutrition.

Synbio consumption improved bowel habits of volunteers consuming the probiotic foods or capsules. The recovery of probiotic bacteria from the faeces of a cohort of 100 subjects for each supplemented group showed the persistence of strains in the gastrointestinal tract. 

2 Coman et al. (2014) - In vitro evaluation of antimicrobial activity of Lactobacillus rhamnosus IMC 501®, Lactobacillus paracasei IMC 502 and SYNBIO against pathogens - Journal of Applied Microbiology.

These probiotics have great potential to produce antimicrobial compounds that inhibit and control the microbial pathogen growth. These probiotic strains may prove useful in the adjunct treatment with probiotics in cure of different gastrointestinal infections.

3 Coman et al. (2014) - Functional foods as carriers for SYNBIO®, a probiotic bacteria combination - International Food Journal of Microbiology.

The aim of this study was to develop new probiotic food products that include a dose of Synbio. The food products outlined in this study (a mix of dairy and non-dairy) would be excellent vehicles to deliver probiotic health effects because of the high viability of probiotics during the shelf-life of foods and in some cases even after their expiry date.

Verdenelli et al. (2011) - Influence of a combination of two potential probiotic strains, Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502 on bowel habits of healthy adults - Letters in Applied Microbiology.

Daily consumption of food products enriched with the two potential probiotic strains, Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502, contributes to improve intestinal microbiota with beneficial properties and enhances bowel habits of healthy adults. After the intervention, a significant increase in faecal lactobacilli and bifidobacteria were observed in the probiotic group, and stool frequency and stool volume were higher in the probiotic group than in the placebo group. 

L. Rhamnosus IMC / Lactobacillus Rhamnosus / L. Paracasei

Segers et al. (2014) - Towards a better understanding of Lactobacillus rhamnosus GG - Microbial Cell Factories.

Lactobacillus rhamnosus is one of the most widely used probiotic strains. Various health effects are well documented including the prevention and treatment of gastro-intestinal infections and diarrhea, and stimulation of immune responses that promote vaccination or even prevent certain allergic symptoms.

Szajewska et al. (2015) - Systematic review with meta-analysis: Lactobacillus rhamnosus in the prevention of antibiotic-associated diarrhoea in children and adults - Alimentary Pharmacology & Therapeutics.

A review of 12 studies in 1,499 people found that supplementing with L. rhamnosus reduced the risk of antibiotic-related diarrhoea from 22.4% to 12.3%.

Francavilla et al. (2010) - A randomized controlled trial of Lactobacillus in children with functional abdominal pain - Pediatrics.

Lactobacillus-rich foods and supplements have been shown to possibly relieve common IBS symptoms, such as abdominal pain.

Yan et al. (2012) - Lactobacillus rhamnosus: An Updated Strategy to Use Microbial Products to Promote Health - The Journal of Functional Foods.

This strain is better adapted to survive in acidic and basic conditions within your body and can adhere to and colonize your intestinal walls. Such traits give L. rhamnosus a better chance of survival, offering longer-term health benefits.

Verdenelli et al. (2009) - Probiotic properties of Lactobacillus rhamnosus and Lactobacillus paracasei isolated from human faeces - European Journal of Nutrition.

In antimicrobial activity assays, both strains showed inhibitory properties towards selected potential harmful microorganisms, particularly against candida albicans.

Skin Health studies

Camu Camu Fruit Extract (Myrciaria dubia)

Fidelis, et al. (2020) - Camu-camu seed (Myrciaria dubia) - From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient - Food Chemistry.

Camu-camu seed extracts are rich sources of antioxidant phenolics, which work as antioxidants that prevent cellular damage due to free-radical oxidation reactions. 

Paul C. Langley, et al. (2015) - Antioxidant and Associated Capacities of Camu Camu (Myrciaria dubia): A Systematic Review. Journal of Integrative and Complementary Medicine.

A program to increase the visibility of camu camu can contribute substantially not only to the management of inflammatory conditions and its positive contribution to overall good health but also to its potential role in many disease states.

Nhung Quynh Do, et al. (2021) - Camu-Camu Fruit Extract Inhibits Oxidative Stress and Inflammatory Responses by Regulating NFAT and Nrf2 Signaling Pathways in High Glucose-Induced Human Keratinocytes. Graduate School of Biotechnology, Kyung Hee University.

Camu-camu fruit treatment activated the expression of nuclear factor E2-related factor 2 (Nrf2) and subsequently increased the NAD(P)H:quinone oxidoreductase1 (NQO1) expression to protect keratinocytes against high-glucose-induced oxidative stress. These results indicate that camu-camu fruit is a promising material for preventing oxidative stress and skin inflammation induced by high glucose level.

Daniela Fracassetti, et al. (2013) - Ellagic acid derivatives, ellagitannins, proanthocyanidins and other phenolics, vitamin C and antioxidant capacity of two powder products from camu-camu fruit (Myrciaria dubia). Food Chemistry.

Camu-camu is an Amazonian berry rich in antioxidants. 53 Phenolic compounds were characterised by HPLC–MS–MS methods. Proanthocyanidins were the main phenolics in the camu-camu flour. Camu-camu products investigated are a relevant source of ellagitannins, and ellagic acid.

Co Enzyme Q10

Vollmer, et al. (2018) - Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome - International Journal of Molecular.

The application of: (a) topical administration from outside into the skin and (b) inside by oral consumption of nutritionals to the outer skin layers is now commonplace and many journal reports exhibit significant improvement for both on a variety of dermal parameters. 

  1. Prahl, et L. (2009) - Aging skin is functionally anaerobic: Importance of coenzyme Q10 for anti aging skin care. IUBMB Journals. 

CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.

Katja Žmitek, et al. (2016) - The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. - IUBMB Journals.

This study investigated the effects of 12 weeks of daily supplementation with 50 and 150 mg of CoQ10 on skin parameters and condition. The intake of CoQ10 limited seasonal deterioration of viscoelasticity and reduced some visible signs of ageing. We determined significantly reduced wrinkles and microrelief lines, and improved skin smoothness.

Silke B.Lohan, et al. (2015) - Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress. European Journal of Pharmaceutics and Biopharmaceutics.

In comparison with the CoQ10-loaded conventional carriers, usNLC-CoQ10 demonstrated the strongest reduction of the radical formation; reaching up to 23% compared to control cells without nanocarrier treatment. Therefore, usNLC-CoQ10 are very suitable to increase the antioxidant potential of skin.


Dilokthornsakul, et al. (2019) - The clinical effect of glutathione on skin color and other related skin conditions: A systematic review - Journal of Cosmetic Dermatology.

We found that both oral glutathione with the dosage of 500 mg/day and topical 2.0% oxidized glutathione could brighten skin color in sun-exposed area measured by skin melanin index.

Sinee Weschawalit, et al. (2017) - Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 

Healthy female subjects were equally randomized into three groups and took GSH (250 mg/d), GSSG (250 mg/d), or placebo orally for 12 weeks. At each visit at baseline and for 12 weeks, skin features including melanin index, wrinkles, and other relevant biophysical properties were measured. At some sites evaluated, subjects who received GSH showed a significant reduction in wrinkles compared with those taking placebo. This study showed that oral glutathione, 250 mg/d, in both reduced and oxidized forms effectively influences skin properties. 

Grapeseed Extract (Vitis vinifera)

Sano, et al. (2007) - Beneficial effects of grape seed extract on malondialdehyde-modified LDL - Journal of Nutritional Science and Vitaminology (Tokyo).

Subjects with high levels of MDA-LDL/ApoB (MDA-LDL/ApoB≥100 mU/mL) in the 200 mg group showed significantly (p=0.011) reduced MDA-LDL levels at 12 wk after the start of administration. In the 400 mg group, significant decreases in MDA-LDL level compared to the basal level were seen 6 and 12 wk after the start of administration (6 wk: p=0.001, 12 wk: p<0.001); and at week 6, significantly (p=0.048) lower values were observed compared to those in patients who took placebo tablets (0 mg proanthocyanidin). These results suggested that tablets containing grape seed extract exerted reducing effects on oxidized LDL, and might be useful in preventing lifestyle-related diseases such as arteriosclerosis.

Madhavi Gupta, et al. (2020) - Grape seed extract: having a potential health benefits. Journal of Food Science and Technology.

Besides being a wellspring for vitamins and fibre, the skin and seeds of grapes are highly rich in Polyphenols specifically proanthocyanidins, which can be used as a functional ingredient to address various health issues by boosting the natural bio-processes of the body.

John Shi, et al. (2004) - Polyphenolics in Grape Seeds—Biochemistry and Functionality. Journal of Medicinal Food.

Extensive research suggests that grape seed extract is beneficial in many areas of health because of its antioxidant effect to bond with collagen, promoting youthful skin, cell health, elasticity, and flexibility. Other studies have shown that proanthocyanidins help to protect the body from sun damage, to improve vision, to improve flexibility in joints, arteries, and body tissues such as the heart, and to improve blood circulation by strengthening capillaries, arteries, and veins.

Vitamins A, C, D & E

Pullar, et al. (2017) - The Roles of Vitamin C in Skin Health - Nutrients.

We compare the efficacy of nutritional intake of vitamin C versus topical application, identify the areas where lack of evidence limits our understanding of the potential benefits of vitamin C on skin health, and suggest which skin properties are most likely to benefit from improved nutritional vitamin C intake.

Nguyen, et al. (2012) - Systemic antioxidants and skin health. Journal of Drugs in Dermatology.

Most dermatologists agree that antioxidants help fight free radical damage and can help maintain healthy skin. They do so by affecting intracellular signaling pathways involved in skin damage and protecting against photodamage, as well as preventing wrinkles and inflammation.

Moores, J. (2013) - Vitamin C: a wound healing perspective - British Journal of Community Nursing.

After wounding, plasma and tissue levels of AA diminish and, as a consequence, supplements may be useful for healing, although levels beyond saturation are excreted. 

  1. Nachbar, et al. (1995) - The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine.

Many studies document that vitamin E occupies a central position as a highly efficient antioxidant, thereby providing possibilities to decrease the frequency and severity of pathological events in the skin. 

Jens J.Thiele, et al. (2007) - Vitamin E in human skin: Organ-specific physiology and considerations for its use in dermatology. Molecular Aspects of Medicine.

Experimental evidence suggests that topical and oral vitamin E has antitumorigenic, photoprotective, and skin barrier stabilizing properties. 

Bodo Lehmann, et al. (2004) - Vitamin D and skin: new aspects for dermatology. Experimental Dermatology. 

Increasing evidence now indicates that cutaneous vitamin D synthesis is of great importance for the prevention of a broad variety of diseases, including various malignancies.

Probiotics for skin health - general studies

Al-Ghazzewi, F.H, et al. (2014) - Impact of prebiotics and probiotics on skin health. Beneficial Microbes.

Nutritional products containing prebiotics and/or probiotics have a positive effect on skin by modulating the immune system and by providing therapeutic benefits for atopic diseases. This review underlines the potential use of pre- and probiotics for skin health.

Jinyan Yu MM, et al. (2022) - Application and mechanism of probiotics in skin care: A review. Journal of Cosmetic Dermatology. 

Probiotics have potent effects on skin whitening, moisturizing, anti-aging, anti-wrinkle and removing body odor.

Lactobacillus Rhamnosus LB21

W, et al. (2017) - Evaluation of efficacy and safety of Lactobacillus rhamnosus in children aged 4-48 months with atopic dermatitis: An 8-week, double-blind, randomized, placebo-controlled study. Journal of Microbiology, immunology & Infection.

The results of this study indicated that L. rhamnosus was effective in decreasing symptoms of atopic dermatitis after an 8-week treatment by comparing the mean change of SCORAD from baseline with a placebo (p < 0.05). Patients who took L. rhamnosus for 8 weeks expressed less SCORAD in the three components: area of affected skin, intensity of atopic dermatitis, and patient symptoms, with a significant decrease in the mean change of intensity from baseline compared with placebo.

European Food Safety Authority (EFSA). (2011) - Scientific Opinion on the substantiation of health claims related to Lactobacillus rhamnosus LB21 NCIMB 40564 and contribution to maintaining individual intestinal microbiota in subjects receiving antibiotic treatment (ID 1061) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. European Food Safety Journal.

No positive claims were made from this 

Lactobacillus Rhamnosus SP1

Fabbrocini, G, et al. (2016) - Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Beneficial Microbes.

conclude that supplementation with the probiotic strain LSP1 normalises skin expression of genes involved in insulin signalling and improves the appearance of adult acne.

Lactobacillus Rhamnosus 

Beata Imko-Walczuk, et al. (2019) - Soothing Efficacy and Tolerability of a Skin Care Product Containing Live Lactobacillus rhamnosus Bacteria and Berry Seed Oils on Atopic Dermatitis Lesions. Journal of Cosmetics, Dermatological Sciences and Applications.

A visible improvement in skin aspect was observed in 67% of the subjects on week 4. On average, the intensity of pruritus decreased by 57% as compared to baseline (p = 0.011). This effect was observed in 86% of the subjects. No relevant adverse reactions were observed following treatment with the skin care product and the majority of the subjects appreciated the product for its general characteristics, properties, and efficacy. 

Ye-On Jung, et al. (2019) - Lysates of a Probiotic, Lactobacillus rhamnosus, Can Improve Skin Barrier Function in a Reconstructed Human Epidermis Model. Int. J. Mol. Sci. 

This study demonstrated that LR lysate has protective effects on the skin barrier, which could expand the utility of probiotics to skin-moisturization ingredients.

Holowacz, S, et al. (2018) - Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice. Beneficial Microbes.

These results obtained in mice suggest that L. salivarius LA307 and L. rhamnosus LA305 could be good candidates for preserving skin integrity and homeostasis via the modulation of the gut microbiota and that their use could be beneficial in dermatological conditions such as AD.

Al-Ghazzewi, et al. (2014) - Impact of prebiotics and probiotics on skin health. Beneficial Microbes.

Nutritional products containing prebiotics and/or probiotics have a positive effect on skin by modulating the immune system and by providing therapeutic benefits for atopic diseases. 

Immune Boost Studies 

Acerola Cherry Fruit Extract

Xu et al. (2020) - Metabolomic analysis of acerola cherry (Malpighia emarginata) fruit during ripening development via UPLC-Q-TOF and contribution to the antioxidant activity - Food Research International (Ottowa).

Acerola cherry showed very different metabolite profile and antioxidant activities during the fruit ripening development. The maturity of Acerola cherry has to be considered when it is being used for health food products.

Cefali, et al. (2018) - Vitamin C in Acerola and Red Plum Extracts: Quantification via HPLC, in Vitro Antioxidant Activity, and Stability of their Gel and Emulsion Formulations - Journal of AOAC International.

Extracts from red plum and acerola contained vitamin C; antioxidant activity of the extracts resulted in over 90.0% inhibition of free radicals.

Meri P. Nantz et al. (2006) - Immunity and Antioxidant Capacity in Humans Is Enhanced by Consumption of a Dried, Encapsulated Fruit and Vegetable Juice Concentrate - The Journal of Nutrition.

FVJC (fruit and vegetable juice powder concentrate containing acerola cherry fruit extract) consumption during this study period resulted in increased plasma nutrients and antioxidant capacity, reduction in DNA strand breaks, and an increase in circulating γδ-T cells.

Tarun Belwal et al. (2018) - Phytopharmacology of Acerola (Malpighia spp.) and its potential as functional food - Trends in Food Science & Technology.

Acerola fruits are well known for their high contents of vitamin C, phenolic compounds and carotenoids. The extracts and compounds isolated from Acerola showed various health promoting activities. Acerola fruits can be good candidates for the development of novel functional foods.

BIO-I10S‡ (Live bacteria blend)

Garcia-Castillo, et al. (2020) - Alveolar Macrophages Are Key Players in the Modulation of the Respiratory Antiviral Immunity Induced by Orally Administered Lacticaseibacillus rhamnosus CRL1505 - Frontiers in Immunology.

Evidence was provided of the important role of CD4+ cells and IFN-γ in the activation of alveolar macrophages highlighting a putative pathway through which the intestinal and respiratory mucosa are communicated under the influence of L. rhamnosus CRL1505.

Kitazawa, et al. (2014) - Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505 - Frontiers in Immunology.

This review examines the most recent advances dealing with the use of immunobiotic bacteria to improve resistance against viral respiratory infections. It was demonstrated that some orally administered immunobiotics do have the ability to stimulate respiratory immunity and increase resistance to viral infections.

Villena, et al. (2012) - Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C) - BMC Immunology.

Results showed that Lr1505 would induce a mobilization of cells from intestine and changes in cytokine profile that would be able to beneficially modulate the respiratory mucosal immunity. 

Ash, Michael. (2009) - Lactobacillus GG: A Potent Immune Regulator Effective in Many Disorders - Clinical Education.

Lactobacillus GG denatures toxins, decreases the inflammatory response, and produces peptides that balance the immune response while limiting the destructive potential of many pathogens.

Echinacea Extract

Hudson, J. (2012) - Applications of the Phytomedicine Echinacea purpurea (Purple Coneflower) in Infectious Diseases - Journal of Biomedicine and Biotechnology.

Recent studies have revealed that certain standardized preparations contain potent and selective antiviral and antimicrobial activities. In addition, they display multiple immune-modulatory activities, comprising stimulation of certain immune functions such as phagocytic activity of macrophages and suppression of the proinflammatory responses of epithelial cells to viruses and bacteria.

H.Hall et al. (2007) - Echinacea Purpurea and Mucosal Immunity - Int J Sports Med.

The results suggest that Echinacea may attenuate the mucosal immune suppression known to occur with intense exercise and reduce the duration of URTI that subjects incur.

Mariangela Rondanelli et al. (2018) - Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds—Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds - Evidence-Based Complementary and Alternative Medicine.

Regarding Echinacea, prophylactic treatment with this extract (2400 mg/day) over 4 months appeared to be beneficial for preventing/treating CC. In conclusion, the current evidence of efficacy for zinc, vitamins D and C, and Echinacea is so interesting that CC patients may be encouraged to try them for preventing/treating their colds.

Turmeric Extract

Hanai, et al. (2009) - Curcumin has bright prospects for the treatment of inflammatory bowel disease - Current Pharmaceutical Design.

Curcumin significantly reduced clinical relapse in patients with quiescent IBD. The inhibitory effects of curcumin on major inflammatory mechanisms like COX-2, LOX, TNF-α, IFN-γ, NF-κB and its unrivalled safety profile suggest that it has bright prospects in the treatment of IBD.

Dilip Kumar Chowdhury et al. (2021) - Feeding turmeric in combination with ginger or garlic enhances the digestive enzyme activities, growth and immunity in Labeo rohita fingerlings - Animal Feed Science and Technology.

Growth enhancing potential of turmeric with combination of ginger or garlic. Dietary combination of turmeric with ginger or garlic enhances the digestive, metabolic and anti-oxidative enzyme activities. These feed additives can be used in aquafeed as the potential natural remedies to modulate innate immune function.

Bharat B. Aggarwal et al. (2013) - Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric - Molecular Nutrition Food Research.

Studies over the past decade have indicated that curcumin-free turmeric (CFT) components possess numerous biological activities including anti-inflammatory, anticancer, and antidiabetic activities.

Rahul Kumar Verma et al. (2018) - Medicinal properties of turmeric (Curcuma longa

L.): A review - International Journal of Chemical Studies. 

Turmeric has a wide spectrum of biological actions. These include its anti inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antifertility, antidiabetic, antibacterial, antifungal, antiprotozoal, antiviral, antifibrotic, antivenom, antiulcer, hypotensive and hypocholesteremic activities. For traditional Ayurvedics, turmeric plant was an excellent natural antiseptic, disinfectant, anti-inflammatory, and analgesic, while at the same time the plant has been often used to aid digestion, to improve intestinal flora, and to treat skin irritations. 

Vitamins A, C and D3

Iddir, et al. (2020) - Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis - Nutrients.

Dietary fiber, fermented by the gut microbiota into short-chain fatty acids, has also been shown to produce anti-inflammatory effects. In this review, we highlight the importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system.

Robyn M. Lucas et al. (2014) - Vitamin D and Immunity - Prime Reports. 

itamin D status may influence the bacterial flora that constitute the microbiome and affect immune function through this route. Exposure of the skin to ultraviolet radiation causes the production of a range of chemicals, including vitamin D, and new research is exploring possible vitamin D-independent immunomodulatory pathways.

S Maggini et al. (2010) - Essential Role of Vitamin C and Zinc in Child Immunity and Health - International Medical Research.

There is increasing evidence that deficiency of vitamin C and zinc adversely affects the physical and mental growth of children and can impair their immune defences. Nutrition should be the main vehicle for providing these essential nutrients; however, supplementation can represent a valid support method, especially in developing regions.

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