References

References, By Product.

Do you know what’s in your gut, skin, and immune care products? At The Gut Co., we want to help you make healthy choices, and those choices start with understanding the ingredients in your supplements.

Our References page is here to provide you with the clinical studies and comprehensive information necessary to make smart and informed decisions about what you put into your body.




Gut Care Studies

As more studies reveal that gut health is a barometer of general health, we understand how the food we feed our gut microbiome plays a critical role in our overall well-being. We know that your gut is high priority, and that high-quality supplements yield high-quality results, which is why we’ve formulated Gut Care using only clinically-studied ingredients proven to bring your microbiome back into balance.

The following ingredients were included in our Gut Care formula for their well-studied ability to help establish and maintain a diversity of microflora in the intestines and rebalance the gut microbiome.



Actazin®


4 Ansel et al. (2015). Kiwifruit-derived supplements increase stool frequency in healthy adults: a randomized, double-blind, placebo-controlled study, Nutrition Research.


5 Blatchford et al. (2017).
Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomised controlled human trial,Journal of Nutritional Science.


Saccharomyces Boulardii


5 6 McFarland, L. (2010). Systematic review and meta-analysis of Saccharomyces boulardii in adult patients, World Journal of Gastroenterology.


Synbio®


1 Silvie et al. (2014). Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines, International Journal of Food Sciences & Nutrition.


2 Coman et al. (2014). In vitro evaluation of antimicrobial activity of Lactobacillus rhamnosus IMC 501®, Lactobacillus paracasei IMC 502 and SYNBIO against pathogens, Journal of Applied Microbiology.


3 Coman et al. (2014) Functional foods as carriers for SYNBIO®, a probiotic bacteria combination, International Food Journal of Microbiology.




Skin Health Studies

An unhealthy gut is one of the most common causes of skin problems and irritation. That’s why we created Skin Health: a unique blend of premium-quality live bacteria, vitamins, and botanicals chosen for their ability to restore balance to your intestinal microbiome and heal the gut-skin axis. In crafting this formula, our team of scientists used a variety of clinically-tested ingredients proven to promote the growth of beneficial bacteria and nourish your skin from within.

The following ingredients were included in our Skin Care formula for their well-studied benefits to the gut microbiome and ability to help reduce skin irritation and inflammation.



Camu Camu Fruit Extract (Myrciaria dubia)


8 Fidelis, et al. (2020). Camu-camu seed (Myrciaria dubia) - From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient, Food Chemistry.


Co Enzyme Q10


7 Vollmer, et al. (2018). Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome, International Journal of Molecular


Glutathione


6 Dilokthornsakul, et al. (2019). The clinical effect of glutathione on skin color and other related skin conditions: A systematic review, Journal of Cosmetic Dermatology.


Grapeseed Extract (Vitis vinifera)


4 Sano, et al. (2007). Beneficial effects of grape seed extract on malondialdehyde-modified LDL, Journal of Nutritional Science and Vitaminology (Tokyo).


5 Moores, J. (2013). Vitamin C: a wound healing perspective, British Journal of Community Nursing..


Lactobacillus Rhamnosus LB21


2 W, et al. (2017). Evaluation of efficacy and safety of Lactobacillus rhamnosus in children aged 4-48 months with atopic dermatitis: An 8-week, double-blind, randomized, placebo-controlled study, Journal of Microbiology, immunology & Infection


3 European Food Safety Authority (EFSA). (2011). Scientific Opinion on the substantiation of health claims related to Lactobacillus rhamnosus LB21 NCIMB 40564 and contribution to maintaining individual intestinal microbiota in subjects receiving antibiotic treatment (ID 1061) pursuant to Article 13(1) of Regulation (EC) No 1924/2006, European Food Safety Journal.


Lactobacillus Rhamnosus SP1


1 Fabbrocini, et al. (2016). Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne, Beneficial Microbes.


Vitamins A, C, D & E


9 Pullar, et al. (2017). The Roles of Vitamin C in Skin Health, Nutrients.


10 Nguyen, et al. (2012). Systemic antioxidants and skin health, Journal of Drugs in Dermatology.




Immune Boost Studies

Your immune health depends in large part on the health of your intestinal microbiome, which means that our guts are one of our first lines of defense against illness. At The Gut Co., we don’t believe in wasting time on filler ingredients: our team engineered Immune Boost to include only the most potent antioxidants, anti-inflammatories, and probiotics that have been scientifically-proven to boost your immune system and help your body defend against virus and infection.

The following ingredients were included in Immune Boost for their well-studied function of reducing oxidative stress and inflammation, respiratory illness, and other benefits to immune health.



Acerola Cherry Fruit Extract


4 Xu et al. (2020). Metabolomic analysis of acerola cherry (Malpighia emarginata) fruit during ripening development via UPLC-Q-TOF and contribution to the antioxidant activity, Food Research International (Ottowa).


5 Cefali, et al. (2018). Vitamin C in Acerola and Red Plum Extracts: Quantification via HPLC, in Vitro Antioxidant Activity, and Stability of their Gel and Emulsion Formulations, Journal of AOAC International.


BIO-I10S‡ (Live bacteria blend)


Garcia-Castillo, et al. (2020). Alveolar Macrophages Are Key Players in the Modulation of the Respiratory Antiviral Immunity Induced by Orally Administered Lacticaseibacillus rhamnosus CRL1505, Frontiers in Immunology.


Kitazawa, et al. (2014). Modulation of Respiratory TLR3-Anti-Viral Response by Probiotic Microorganisms: Lessons Learned from Lactobacillus rhamnosus CRL1505, Frontiers in Immunology.


Villena, et al. (2012). Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C), BMC Immunology.


Ash, Michael. (2009). Lactobacillus GG: A Potent Immune Regulator Effective in Many Disorders(article), Clinical Education.


Echinacea Extract


3 Hudson, J. (2012). Applications of the Phytomedicine Echinacea purpurea (Purple Coneflower) in Infectious Diseases, Journal of Biomedicine and Biotechnology.


Turmeric Extract


2 Hanai, et al. (2009). Curcumin has bright prospects for the treatment of inflammatory bowel disease, Current Pharmaceutical Design.


Vitamins A, C and D3


1 Iddir, et al. (2020). Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis, Nutrients.


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